
presents
For the developers and the builders.
June 24th - 26th 2025 | Industry City, Brooklyn, NY
For those with a dream.
As the focus shifts from infrastructure to applications, Permissionless IV serves as the definitive gathering for crypto's technical founders, developers, and builders to come together and create the future.


Includes a free non-transferable ticket to Permissionless IV. Applications will be reviewed on a rolling basis. You can expect to be notified of your status within 1-4 business days of submission.
Applications will be reviewed on a rolling basis.
Discounts available for groups of 5+. Register today and save!
Main Stage
9:15 AM - 9:30 AM
Welcome to Permissionless IV


9:30 AM - 9:50 AM
What Are We Building Towards?

9:50 AM - 10:10 AM
Making NYC the Crypto Capital of the World


10:10 AM - 10:35 AM
In Conversation with Peter Todd


10:35 AM - 10:40 AM
USPD: Permissionless Money

10:40 AM - 11:00 AM
The Next Bottleneck: Rethinking Real-time Infrastructure


11:00 AM - 11:20 AM
The Unintended Consequences of Digital Asset ETFs


11:20 AM - 11:40 AM
The Rise of AutoFi & System-Level Automation

11:40 AM - 12:20 PM
Live: 0xResearch Roundup




12:20 PM - 12:30 PM
Introducing: Quality Active Addresses (QAAs)

Consumer Applications
1:30 PM - 2:10 PM
The Next Generation of Consumer Crypto Apps




2:10 PM - 2:30 PM
Putting Easy-to-Use DeFi In Everyones Pocket


3:10 PM - 3:50 PM
Creating Bulletproof Onchain Games





Protocol R&D
1:30 PM - 2:10 PM
The Optimal Tradeoffs for Protocol Design




2:10 PM - 2:30 PM
Permissionless MEV

2:30 PM - 3:10 PM
The Past, Present, and Future of MEV





3:10 PM - 3:50 PM
The Ethereum L2 State of the Union





3:50 PM - 4:30 PM
Hackathon Awards
Bitcoin
1:30 PM - 2:10 PM
Bitcoin DeFi: Making BTC a Productive Asset





2:10 PM - 2:30 PM
Debate: How Should Bitcoin Scale?



2:30 PM - 3:10 PM
Where to Build in the Bitcoin Network




3:10 PM - 3:30 PM
Bitcoin & The Energy to Compute Value Chain


3:30 PM - 4:20 PM
The Core Dev's Guide to Bitcoin Network Upgrades



DePin
1:30 PM - 2:10 PM
Onchain Iconoclasts: DePin's Disruption of Traditional Business Models





2:10 PM - 2:40 PM
Decentralizing Forces in the AI Stack



2:40 PM - 3:10 PM
Revamping the Consumer Internet Experience



3:10 PM - 3:50 PM
Pushing the Outer Limits of Compute



3:50 PM - 4:30 PM
The DePin x AI Confluence





Main Stage
9:10 AM - 9:30 AM
DeFi's Next Frontier: In Conversation with Hayden Adams


9:30 AM - 9:50 AM
The Machine Economy Computer: Blockchain's Ultimate Product-Market Fit

9:50 AM - 10:00 AM
Build Like Infinex

10:00 AM - 10:20 AM
How to Build Through Bull & Bear Markets


10:20 AM - 10:40 AM
The Next Generation of Financial Markets


10:40 AM - 11:00 AM
In Conversation with World Liberty Financial


11:00 AM - 11:20 AM
Unlocking BTCFi

11:20 AM - 11:25 AM
Everything is a Bank

11:25 AM - 11:45 AM
Privacy & The User-First Web


11:45 AM - 12:05 PM
The Bitcoin Yield Flywheel

12:05 PM - 12:30 PM
The Next Frontier for Crypto & AI


DeFi Renaissance
1:30 PM - 2:10 PM
The DeFi Renaissance is Here





2:10 PM - 2:50 PM
America: Land of the Free, Home of the Chains



2:50 PM - 3:00 PM
Surveying the DEX Landscape

3:00 PM - 3:15 PM
Consulting vs Curation: New Models for Risk Management

3:15 PM - 3:35 PM
Multichain DeFi & The Quest for Yield


3:35 PM - 3:55 PM
In Conversation with Privy


3:55 PM - 4:30 PM
The Yield Frontier: Trading the Future of Onchain Rates



Blockchain Design
1:30 PM - 2:10 PM
Debate: How Should Ethereum Scale?



2:10 PM - 2:50 PM
Debate: How Should Protocols Monetize Blockspace?





2:50 PM - 3:30 PM
The Future of Security is Zero-Knowledge




3:30 PM - 4:00 PM
Debate: Can Everything Fit on One Computer?





4:00 PM - 4:30 PM
Making the EVM Faster than Solana



Capital Deployoors
1:30 PM - 2:10 PM
Bringing the Long Tail of Markets Onchain




2:10 PM - 2:50 PM
The Crypto Venture State of the Union




2:50 PM - 3:30 PM
Live: Forward Guidance Roundup



3:30 PM - 3:50 PM
The Tokenization of Private Markets


3:50 PM - 4:50 PM
Pitch @ Permissionless: Go To Market Workshop




Crypto x AI
1:30 PM - 2:10 PM
Game Theorizing about the Future of Crypto x AI





2:10 PM - 2:30 PM
Beyond GPUs: How Decentralization Can Solve AI's Biggest Scaling Bottleneck

2:30 PM - 3:10 PM
The Existential Need for Open-Source AI




3:10 PM - 3:30 PM
Digital Identity's Destruction of the 20 Year Monopoly in Data


3:50 PM - 4:30 PM
Empowering the Builders of the Open Internet



Main Stage
9:20 AM - 9:50 AM
Unpacking the Token Acquisition Vehicle Meta




9:50 AM - 10:30 AM
Live: Empire x Bell Curve Roundup




10:30 AM - 11:05 AM
Turning the Ship Around: Where Ethereum Goes From Here



11:05 AM - 11:25 AM
Onchain Intelligence & the Future of Crypto Trading

11:25 AM - 11:50 AM
In Conversation with Li Fan, CTO of Circle

11:50 AM - 12:30 PM
Permissionless IV Recap






Token Design
1:30 PM - 2:10 PM
How Should Tokens Be Used In Capital Allocation?




2:00 PM - 2:30 PM
Tokens vs Equity: A Better Path Forward

2:30 PM - 3:10 PM
The Proliferation of Stablecoin Models



3:10 PM - 3:30 PM
Increasing the Velocity of Dollars

3:30 PM - 4:00 PM
Crypto's Desperate Need for Token Transparency


How to Build a Chain
1:30 PM - 2:20 PM
Crafting Incentive Programs That Actually Work



2:10 PM - 2:30 PM
Fireside Chat with Wormhole and Ripple


2:30 PM - 3:10 PM
Interop in the Land of 1000 Chains



3:10 PM - 3:50 PM
ZK & Crypto's [redacted] Endgame



Enterprise
1:30 PM - 2:10 PM
Rebooting the Global Financial System





2:10 PM - 2:30 PM
Crypto Meets Cards: Shaping the Future of Commerce


2:30 PM - 2:50 PM
Permissioned vs Permissionless Chains for Enterprise Use


2:50 PM - 3:30 PM
Unleashing Payments at the Speed of the Internet





3:30 PM - 4:00 PM
Clearing Skies: Crypto Company Building in the US




Open Source AI
1:15 PM - 1:20 PM
How AI is changing early AI projects and what it means
1:20 PM - 1:40 PM
Academic Research in the Era of LLMs
1:40 PM - 2:00 PM
The Blockchain for AI, Explained

2:00 PM - 2:20 PM
Eigencloud: supercharging verifiable AI

2:20 PM - 2:50 PM
Debate Round 2: Security Models for Verifiable Machine Learning



2:50 PM - 3:10 PM
AITP: A Payments Protocol for AI Agent Economies

3:10 PM - 3:50 PM
Superintelligence Needs The Supercloud: Why the AI Revolution Hinges on Our Energy Grid

4:10 PM - 4:40 PM
AI Products that are actually going to work



4:40 PM - 4:50 PM
User-owned AI and the new data economy

3:50 PM - 2:10 PM
Optimizing Rewards in the age of DeepSeek































































































































Peter Todd
Founder, OpenTimestamps
Brendan Eich
Co-Founder & CEO, Brave
Kain Warwick
Founder, Infinex
Hayden Adams
Founder & CEO , Uniswap Labs

June 22–23, 2025 in Brooklyn, NY.
RWAs. American Dynamism. Reshoring DeFi Talent. US-based Capital Formation. DeFi apps.
Onchain Applications. Mobile Apps. Prediction Markets. NFTs. Onchain Gaming. Loyalty Engines. Creator Economy.
Blockchain design. EVM. SVM. Move. Modular vs Monolithic. Rollups. Scaling. Parallelization. Privacy & Security. ZK Proofs.
Tokenomics. Token Generation Events. Cash Flows and Fee Switches. Utility. Governance. Equity.
Open Source Models. Onchain Verifiability. DePIN. Agents. Decentralized GPUs. Incentivized Training.
$BTC Dominance. Bitcoin Network Development. Scaling Bitcoin. Institutional & Nation State Adoption.








































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