Podcast: 2022 Crypto Theses with Ryan Selkis

Ryan Selkis and Mike Ippolito take a big seat to talk big predictions for crypto come 2022, including NFTs, Web 3, DAOs, and more.

by Brianna Beckford /
article-image
share

On this episode of Blockworks’ podcast On the Margin, Michael Ippolito, co-founder, is joined by Ryan Selkis, co-founder and CEO at Messari.

Having released the 150+ page Crypto Theses for 2022 report, we invited Ryan to the show to discuss the most important trends to look out for in the industry. Mike and Ryan discuss the layer-1 wars, venture capital investment in crypto, NFTs 100x potential, regulation for crypto and decentralized autonomous organizations (DAOs), Ryan’s market outlook for 2022 and so much more.

They also covered:

  • The structure of a DAO
  • Web3
  • and so much more

Watch the full episode down below! 👇

On the Margin is a two-part show. Once a week, Mike interviews industry experts, and then at the end of the week, he is joined by a co-host where they break down the top crypto and macro stories. Episodes go live every Wednesday and Saturday morning.

Subscribe to On the Margin today on Apple or Spotify, or watch episodes on YouTube.

Get the day’s top crypto news and insights delivered to your inbox every evening. Subscribe to Blockworks’ free newsletter now.

Tags

Decoding crypto and the markets. Daily, with Byron Gilliam.

Upcoming Events

Javits Center North | 445 11th Ave

Tues - Thurs, March 24 - 26, 2026

Blockworks’ Digital Asset Summit (DAS) will feature conversations between the builders, allocators, and legislators who will shape the trajectory of the digital asset ecosystem in the US and abroad.

recent research

Unlocked by Template.png

Research

The march toward an interoperable and onchain-by-default internet depends on reliable messaging and value transfer across heterogeneous domains. Crosschain protocols now process >$1.3T in combined annual transfer volume and secure tens of millions of user interactions, yet no single design dominates.

article-image

The goal, per Santiago Santos, is to make crypto a relatable piece of tech for people who may not even understand it

article-image

Stripe stablecoin unit aims to operate under a federal charter enabling regulated stablecoin issuance and custody services

by Blockworks /
article-image

Will TradFi make crypto better or create more problems than it solves?

article-image

Subtle decisions by risk curators saved Aave from significant turmoil

article-image

The new Rootstock Institutional unit aims to connect professional investors to Bitcoin-native yield and liquidity strategies anchored in BTC’s security layer

by Blockworks /
article-image

DOJ files record civil forfeiture against more than 127,000 BTC linked to scam activity

by Blockworks /