Podcast: 2022 Crypto Theses with Ryan Selkis

Ryan Selkis and Mike Ippolito take a big seat to talk big predictions for crypto come 2022, including NFTs, Web 3, DAOs, and more.

by Brianna Beckford /
article-image
share

On this episode of Blockworks’ podcast On the Margin, Michael Ippolito, co-founder, is joined by Ryan Selkis, co-founder and CEO at Messari.

Having released the 150+ page Crypto Theses for 2022 report, we invited Ryan to the show to discuss the most important trends to look out for in the industry. Mike and Ryan discuss the layer-1 wars, venture capital investment in crypto, NFTs 100x potential, regulation for crypto and decentralized autonomous organizations (DAOs), Ryan’s market outlook for 2022 and so much more.

They also covered:

  • The structure of a DAO
  • Web3
  • and so much more

Watch the full episode down below! 👇

On the Margin is a two-part show. Once a week, Mike interviews industry experts, and then at the end of the week, he is joined by a co-host where they break down the top crypto and macro stories. Episodes go live every Wednesday and Saturday morning.

Subscribe to On the Margin today on Apple or Spotify, or watch episodes on YouTube.

Get the day’s top crypto news and insights delivered to your inbox every evening. Subscribe to Blockworks’ free newsletter now.

Tags

Decoding crypto and the markets. Daily, with Byron Gilliam.

Upcoming Events

Javits Center North | 445 11th Ave

Tues - Thurs, March 24 - 26, 2026

Blockworks’ Digital Asset Summit (DAS) will feature conversations between the builders, allocators, and legislators who will shape the trajectory of the digital asset ecosystem in the US and abroad.

recent research

allora-image.png

Research

Decentralized AI coordination networks solve crypto's growing architectural mismatch: applications built on trustless infrastructure shouldn't depend on centralized intelligence providers. By turning model outputs into competitive marketplaces, protocols like Allora are building the permissionless intelligence layer that AI-powered DeFi and autonomous agents require.

article-image

Futuristic DeFi is stuck inside the computer. An old idea might be its escape hatch

article-image

Money market indicators are flashing liquidity stress again as crypto underperforms equities

article-image

From passageways to penumbras: a history of private life

article-image

BTC’s Asia-session move and Ethena’s weaker yields reflect a market adjusting to tighter yen funding and softer derivatives carry

article-image

What Monad’s launch, MegaETH pre-market pricing, and the Berachain refund story say about today’s infra market

article-image

Prediction markets are hitting record volumes, while Neutrl opens one of crypto’s most overlooked yield opportunities