Podcast: 2022 Crypto Theses with Ryan Selkis

Ryan Selkis and Mike Ippolito take a big seat to talk big predictions for crypto come 2022, including NFTs, Web 3, DAOs, and more.

by Brianna Beckford /
article-image
share

On this episode of Blockworks’ podcast On the Margin, Michael Ippolito, co-founder, is joined by Ryan Selkis, co-founder and CEO at Messari.

Having released the 150+ page Crypto Theses for 2022 report, we invited Ryan to the show to discuss the most important trends to look out for in the industry. Mike and Ryan discuss the layer-1 wars, venture capital investment in crypto, NFTs 100x potential, regulation for crypto and decentralized autonomous organizations (DAOs), Ryan’s market outlook for 2022 and so much more.

They also covered:

  • The structure of a DAO
  • Web3
  • and so much more

Watch the full episode down below! 👇

On the Margin is a two-part show. Once a week, Mike interviews industry experts, and then at the end of the week, he is joined by a co-host where they break down the top crypto and macro stories. Episodes go live every Wednesday and Saturday morning.

Subscribe to On the Margin today on Apple or Spotify, or watch episodes on YouTube.

Get the day’s top crypto news and insights delivered to your inbox every evening. Subscribe to Blockworks’ free newsletter now.

Tags

Decoding crypto and the markets. Daily, with Byron Gilliam.

Upcoming Events

Javits Center North | 445 11th Ave

Tues - Thurs, March 24 - 26, 2026

Blockworks’ Digital Asset Summit (DAS) will feature conversations between the builders, allocators, and legislators who will shape the trajectory of the digital asset ecosystem in the US and abroad.

recent research

Research Report Templates (3).png

Research

South Korea is emerging as one of the most important global hubs for regulated digital assets, and Upbit sits at the center of this shift. Naver’s proposed acquisition could create the country’s dominant super app for payments, trading, and digital finance. This report breaks down the numbers, the regulatory tailwinds, the economics of the deal, and why the merger may unlock one of the most attractive asymmetries in Korea’s public markets.

article-image

As DevConnect kicks off in Buenos Aires, Vitalik and friends call for a reset

article-image

GPUs are starting to go dark even as data-center spending doubles — is a bubble on the horizon?

article-image

Risk assets sold off as doubts loom over a December rate cut, with BTC tumbling briefly below $95K this morning

by Carlos /
article-image

Jeff Yass bets that prediction markets could stop wars, Paul Atkins’ announcement on “tokens,” and more

article-image

Lido unveils a new buyback plan while BTC treasury companies slip below mNAV — can either model can truly return value?

article-image

If financial nihilism has driven you into memecoins, zero-day options, and sports betting, consider financial optimism instead