Bucking Crypto Quant Mania, Equity Vets Bet Investors Are Hungry for Fundamentals

Blockworks Exclusive: The startup, Factor6 Capital, plans to start trading outside capital early next month


Blockworks exclusive art by axel rangel


key takeaways

  • The crypto hedge fund launch is aiming to stand out in a market dominated by quants
  • Its founders have been personally investing in crypto since 2017

A couple of former biotechnology stock traders are vying to bring their investment prowess in the high-risk, high-reward sector to the crypto game.

Ralph Achacoso and Jason Zhang, both alums of healthcare-focused hedge fund firm Ghost Tree Capital, plan to launch their Factor6 Capital at the beginning of next month, according to two sources familiar with the matter.

Achacoso and Zhang are betting institutional investors will see the appeal of a discretionary, fundamental approach to deriving alpha from digital assets, bucking a trend toward systematic, black-box digital asset strategies. 

Sources said the firm believes few other market players are employing a discretionary approach — which big-time limited partners are accustomed to vetting when it comes to stock-picking portfolio managers. 

The firm started trading internal capital Tuesday in a bid to test its infrastructure before taking on outside investors. 

Achacoso declined to comment. Sources were granted anonymity to discuss sensitive business dealings. 

Factor6 has a broad investment mandate that includes layer-1 and layer-2 protocols, plus metaverse and play-to-earn gaming plays, as well as stocks with blockchain exposures and crypto derivatives. A portion of the book is earmarked for non-fungible tokens (NFTs), too. 

And the firm plans to take opportunistic private stakes, either in the form of equity or tokens, in promising digital asset startups — joining a growing number of liquid traders drawn to booming valuations in venture capital plays.

Achacoso and Zhang — who have personally been investing in crypto since 2017 — intend to make money from both long and short wagers. The idea is to profit from the upside in crypto while controlling for downside volatility. 

It’s not clear how much capital Factor6 plans to raise overall. Indications are the startup hasn’t yet begun a broad fundraising push.

Achacoso, who holds the title of chief investment officer for Factor6, worked at Ghost Tree from 2018 to 2022. Before that, he spent time at firms including PineView Asset Management, UBS and Diamondback Capital.

Zhang, the startup’s co-portfolio manager, spent about five years at Ghost Tree, preceded by stops at Visium Asset Management and Merrill Lynch.

Start your day with top crypto insights from David Canellis and Katherine Ross. Subscribe to the Empire newsletter.

The Lightspeed newsletter is all things Solana, in your inbox, every day. Subscribe to daily Solana news from Jack Kubinec and Jeff Albus.


Upcoming Events

Salt Lake City, UT

WED - FRI, OCTOBER 9 - 11, 2024

Pack your bags, anon — we’re heading west! Join us in the beautiful Salt Lake City for the third installment of Permissionless. Come for the alpha, stay for the fresh air. Permissionless III promises unforgettable panels, killer networking opportunities, and mountains […]

recent research

Screenshot 2024-05-23 091855.png


Bitcoin L2s aim to boost scalability while preserving decentralization and security, unlocking a better user experience, and new avenues for Bitcoin-powered innovations. However, no existing Bitcoin L2 leverages the full security of Bitcoin.



The convergence of AI and blockchain on Polkadot represents a groundbreaking opportunity for investors and developers alike


The company is making public a previously private offer rejected by Bitfarms’ board of directors last month


Semler Scientific, a publicly traded medical tech company, joined MicroStrategy by buying up millions of bitcoin


As someone who’s been knee-deep in the trenches of blockchain development, I can’t help but wonder if these behemoths are really cutting it anymore


UNI and MKR are suffering from the successes of their respective protocols


Maybe there’s no silver bullet to avoiding most tokens dumping after launch…